Substrate: Presenilin 1 (Presenilin 1 (PS-1) (S182 protein))
Seq-ID: P49768 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14193   PKP4_HUMAN
MINT-15987   FLNB_HUMAN
MINT-16205   B2CL1_HUMAN
MINT-17726   FLNA_HUMAN
MINT-49819   CADH1_HUMAN
MINT-2837737   GSK3B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium channel activity,
beta-catenin binding,
endopeptidase activity,
PDZ domain binding		 centrosome,
Golgi membrane,
smooth endoplasmic reticulum,
integral to plasma membrane,
cell surface,
kinetochore,
nuclear outer membrane,
endoplasmic reticulum membrane,
rough endoplasmic reticulum,
gamma-secretase complex		 induction of apoptosis by extracellular signals,
membrane protein ectodomain proteolysis,
anti-apoptosis,
Notch receptor processing,
membrane protein intracellular domain proteolysis,
Notch signaling pathway,
amyloid precursor protein catabolic process,
cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 43 RERQEHNDRRSLGHPEPLSNG - 17081983
HTP
0.72
 - -
0.89
 - medium
S 310 EGDPEAQRRVSKNSKYNAEST PKA_group 14576165
LTP
0.25
 MOD_PKA_1
 - PSN
0.66
 - medium
S 346 FSEEWEAQRDSHLGPHRSTPE PKC_alpha 14576165
LTP
0.24
 - PSN
0.62
 - medium
S 353 QRDSHLGPHRSTPESRAAVQE GSK-3_beta 11104755
LTP
0.15
 MOD_GSK3_1
 - PSN
0.59
 - medium
T 354 RDSHLGPHRSTPESRAAVQEL CDK_group 12056836
LTP
0.11
 - PSN
0.58
 - medium
T 354 RDSHLGPHRSTPESRAAVQEL CDK5 12056836
LTP
0.11
 - PSN
0.58
 - medium
S 357 HLGPHRSTPESRAAVQELSSS GSK-3_beta 11104755
LTP
0.93
 MOD_GSK3_1
 - PSN
0.48
 - medium
S 365 PESRAAVQELSSSILAGEDPE - 18669648
HTP
0.33
 - PSN
0.47
 - medium
S 366 ESRAAVQELSSSILAGEDPEE - 18669648
HTP
0.90
 - PSN
0.46
 - medium
S 367 SRAAVQELSSSILAGEDPEER - 17081983
HTP
0.50
 - PSN
0.44
 - medium
S 367 SRAAVQELSSSILAGEDPEER - 18669648
HTP
0.50
 - PSN
0.44
 - medium

Substrate: Presenilin 1 (Presenilin 1 (PS-1) (S182 protein))
Seq-ID: P49769 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-1958847   EFNB1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cadherin binding,
endopeptidase activity		 neuronal cell body,
cytoplasmic vesicle,
dendritic shaft,
endoplasmic reticulum membrane,
growth cone,
Golgi membrane,
ciliary rootlet,
integral to plasma membrane,
cell surface,
axon		 beta-amyloid metabolic process,
Cajal-Retzius cell differentiation,
negative regulation of axonogenesis,
smooth endoplasmic reticulum calcium ion homeostasis,
cerebral cortex cell migration,
skeletal system morphogenesis,
neuron development,
response to oxidative stress,
brain morphogenesis,
Notch receptor processing,
mitochondrial transport,
regulation of synaptic plasticity,
positive regulation of apoptosis,
post-embryonic development,
anagen,
heart looping,
amyloid precursor protein catabolic process,
synaptic vesicle targeting,
positive regulation of coagulation,
cell fate specification,
memory,
T cell receptor signaling pathway,
embryonic limb morphogenesis,
positive regulation of MAP kinase activity,
positive regulation of protein amino acid phosphorylation,
choline transport,
blood vessel development,
membrane protein ectodomain proteolysis,
dorsal/ventral neural tube patterning,
regulation of synaptic transmission, glutamatergic,
thymus development,
anti-apoptosis,
protein amino acid glycosylation,
protein transport,
regulation of epidermal growth factor receptor activity,
T cell activation involved in immune response,
hemopoietic progenitor cell differentiation,
regulation of resting membrane potential,
L-glutamate transport,
Notch signaling pathway,
neuron migration,
neuron apoptosis,
autophagic vacuole assembly,
response to DNA damage stimulus,
myeloid leukocyte differentiation,
epithelial cell proliferation,
negative regulation of protein kinase activity,
regulation of protein binding,
protein maturation by peptide bond cleavage,
somitogenesis,
activation of MAPKK activity,
negative regulation of protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 329 RAERETQDSGSGNDDGGFSEE - 19144319
HTP
0.78
 - PSN
0.75
 - medium
S 365 PESRAAVQELSGSILTSEDPE - 19144319
HTP
0.16
 - PSN
0.52
 - medium
S 367 SRAAVQELSGSILTSEDPEER - 15345747
HTP
0.58
 - PSN
0.49
 - medium
S 367 SRAAVQELSGSILTSEDPEER - 17242355
HTP
0.58
 - PSN
0.49
 - medium
S 367 SRAAVQELSGSILTSEDPEER - 19144319
HTP
0.58
 - PSN
0.49
 - medium
T 370 AVQELSGSILTSEDPEERGVK - 15345747
HTP
0.16
 - PSN
0.43
 - medium
T 370 AVQELSGSILTSEDPEERGVK - 17242355
HTP
0.16
 - PSN
0.43
 - medium
T 370 AVQELSGSILTSEDPEERGVK - 19144319
HTP
0.16
 - PSN
0.43
 - medium
S 371 VQELSGSILTSEDPEERGVKL - 17242355
HTP
0.55
 - PSN
0.41
 - medium
S 371 VQELSGSILTSEDPEERGVKL - 19144319
HTP
0.55
 - PSN
0.41
 - medium

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